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Induced pluripotent stem cell-derived dopaminergic cultures reveal a signature in patients with YOPD who have no known Parkinson’s disease-related mutations, suggesting that there might be other genetic contributions to this disorder. This signature was normalized by specific phorbol esters, making them promising therapeutic candidates.

Read more in Nature Medicine 2020 Feb. Vol. 26; 289–299

doi: 10.1038/s41591-019-0739-1

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